Sam Prendergast has been cleared to start for Ireland in their Nations Championship meeting with Argentina on Friday.

The 23-year-old has shaken off a wrist injury to get the 10 jersey for Friday night's meeting with Los Pumas, with Connacht's Ciarán Frawley supplementing him off the bench.

Head coach Andy Farrell has made seven changes to the side that started Ireland's last outing, a 40-21 defeat to New Zealand in Auckland in July.

Farrell has made two big calls in particular, with Craig Casey given an opportunity to start at scrum-half.

The Munster nine comes in for Jamison Gibson-Park, who is named among the replacements, having only made one appearance for Leinster this season.

Nick Timoney has also been preferred to Josh van der Flier at blindside flanker, as the Ulster back row cements his importance in the Ireland squad. The 31-year-old will win his 15th cap on Friday evening, having played in 10 of Ireland's last 11 games.

Robbie Henshaw gets the nod to start at outside centre in the absence of the injured Garry Ringrose, while Ryan Baird, Andrew Porter and Mack Hansen all return to the side after missing the summer tour due to injury.

Dan Sheehan captains the side from hooker, with Porter and Tadhg Furlong the starting props, while Rónan Kelleher, Tom O'Toole and Sam Illo are the front row replacements.

Joe McCarthy and Tadhg Beirne are partnered in the second row, as James Ryan is named on the bench, while Baird, Timoney and Jansen start as a back row trio for the first time.

Casey and Prendergast team up behind the scrum, with Stuart McCloskey and Robbie Henshaw in the centre, and Bundee Aki beating Jamie Osborne, Tommy O'Brien and Jimmy O'Brien to a bench spot.

Hugo Keenan is named at full-back, with Hansen and Rob Baloucoune on the wings.

Meanwhile, Los Pumas have made sweeping changes to the team that drew 28-28 with Australia in September, with loosehead prop Boris Wegner and number 8 Pablo Matera the only players retained in the starting side.

Full-back Santiago Carreras and prop Thomas Gallo are among those who are unavailable due to injury.

Ireland: Hugo Keenan; Rob Baloucoune, Robbie Henshaw, Stuart McCloskey, Mack Hansen; Sam Prendergast, Craig Casey; Andrew Porter, Dan Sheehan (capt), Tadhg Furlong; Joe McCarthy, Tadhg Beirne; Ryan Baird, Nick Timoney, Sean Jansen.

Replacements: Rónan Kelleher, Tom O'Toole, Sam Illo, James Ryan, Josh van der Flier, Jamison Gibson-Park, Ciarán Frawley, Bundee Aki

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