Bianca Andreescu's quest to return to the top of the tennis world continues on Thursday when she takes on Maria Sakkari in the semifinals of the 2021 Miami Open at Hard Rock Stadium in Miami Gardens, Fla. The 2019 U.S. Open champion, Andreescu sat out 15 months because of a left knee injury and the coronavirus pandemic. Her run in South Florida is her best result since returning to tournament tennis two months ago. On Thursday she'll face Sakkari, who upset Naomi Osaka in the quarterfinals on Wednesday.

The match is set to begin no sooner than 8:30 p.m. ET. William Hill Sportsbook lists Sakkari as a -118 favorite (risk $118 to win $100) in the latest Sakkari vs. Andreescu odds, with Andreescu listed at -105 as the underdog. You can also pick whether Andreescu will cover the 1.5-game spread and how many games the match will last, among other wagering options in the 2021 Miami Open odds. Before making any Andreescu vs. Sakkari picks, be sure to see the 2021 Miami Open predictions from elite tennis handicapper Gavin Mair.

Mair is the international women's tennis expert who called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Naomi Osaka (32-1) winning the 2018 U.S. Open and Andreescu (20-1) winning the 2019 U.S. Open. And before the women's singles final in the most recent grand slam, the Australian Open, he picked Osaka to win in straight sets (-162) and for the match to go under 20.5 total games (-118), and he was right on both counts.

Now, Mair has broken down the latest 2021 Miami Open women's semifinal odds and released his coveted best bets for Andreescu vs. Sakkari. He's sharing his picks and analysis at SportsLine.

Now seemingly injury-free, Andreescu is showing off the all-around game that helped her win the U.S. Open and rise to No. 4 in the world. The 20-year-old Canadian has all the shots, from moon balls to a slice forehand. She also has demonstrated peak fitness in South Florida, winning three of her four matches in three sets.

In addition, she is practically unbeatable in North America. Beginning in 2019 Andreescu is 39-2 in matches played in the U.S., Canada or Mexico. And in one of the losses, she was forced to retire because of injury.

Mair is leaning for the match to go over 22.5 total games, but will Andreescu reach the final or will Sakkari continue her shocking run? Mair's picks include a play on the outright winner and how many sets the match will go. Be sure to see Mair's picks and analysis before making your Miami Open 2021 picks for the women's semifinals.

Who wins Sakkari vs. Andreescu? And how many sets does the match go? Visit SportsLine now to see Mair's best bets for Andreesu vs. Sakkari, all from the acclaimed expert who hit big in the last grand slam women's final.